Reversing Hearing Loss – A New Promising Genetic Treatment

Researchers at The Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London have successfully reversed hearing loss in mice.

Their findings, published in the Proceedings of the National Academy of Sciences, detail a genetic method used to restore hearing in mice affected by a faulty Spns2 gene, particularly in the low to middle-frequency areas. Researchers say this proof-of-concept study suggests that hearing impairment resulting from reduced gene activity may be reversible.

Over half of adults in their 70s experience significant hearing loss. Impaired hearing is associated with an increased likelihood of experiencing depression and cognitive decline, as well as being a major predictor of dementia. While hearing aids and cochlear implants may be useful, they do not restore normal hearing function, and neither do they halt disease progression in the ear. There is a significant unmet need for medical approaches that slow down or reverse hearing loss.

Researchers in this study bred mice with an inactive Spns2 gene. Mice were then provided with a special enzyme at differing ages to activate the gene after which their hearing improved. This was found to be most effective when Spns2 was activated at a young age, with the positive effects of gene activation becoming less potent the longer the researchers waited to provide the intervention.

Professor Karen Steel, Professor of Sensory Function at King’s IoPPN and the study’s senior author said, “Degenerative diseases such as progressive hearing loss are often believed to be irreversible, but we have shown that at least one type of inner ear dysfunction can be reversed. We used a genetic method to show this reversal as a proof-of-concept in mice, but the positive results should encourage research into methods like gene therapy or drugs to reactivate hearing in people with a similar type of hearing loss.”

Dr Elisa Martelletti, the study’s first author from King’s IoPPN said, “Seeing the once-deaf mice respond to sounds after treatment was truly thrilling. It was a pivotal moment, demonstrating the tangible potential to reverse hearing loss caused by defective genes. This groundbreaking proof-of-concept study unlocks new possibilities for future research, sparking hope for the development of treatments for hearing loss.”

Reference: “Reversal of an existing hearing loss by gene activation in Spns2 mutant mice” by Elisa Martelletti, Neil J. Ingham and Karen P. Steel, 8 August 2023, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2307355120

This study was possible thanks to funding from the Medical Research Council, Wellcome, and from Decibel Therapeutics Inc.