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    Home»Biology»Scientists Extract Complete Human Genome From 5,700-Year-Old “Chewing Gum” – Here’s What They Found
    Biology

    Scientists Extract Complete Human Genome From 5,700-Year-Old “Chewing Gum” – Here’s What They Found

    By University of Copenhagen The Faculty of Health and Medical SciencesDecember 18, 201975 Comments5 Mins Read
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    Artistic Reconstruction of Lola
    Researchers from the University of Copenhagen have succeeded in extracting a complete ancient human genome from a 5,700-year-old birch pitch. The image is an artistic reconstruction of the woman who chewed the birch pitch and has been named Lola. Credit: Illustration by Tom Björklund

    Researchers from the University of Copenhagen have succeeded in extracting a complete human genome from a thousands-of-years-old “chewing gum”. According to the researchers, it is a new untapped source of ancient DNA. 

    During excavations on Lolland, archaeologists have found a 5,700-year-old type of “chewing gum” made from birch pitch. In a new study, researchers from the University of Copenhagen succeeded in extracting a complete ancient human genome from the pitch.

    It is the first time that an entire ancient human genome has been extracted from anything other than human bones. The new research results were published in the scientific journal Nature Communications on December 17, 2019.

    5,700-Year-Old Birch Pitch
    During excavations on Lolland, Denmark, archaeologists have found a 5,700-year-old birch pitch. Researchers from the University of Copenhagen have succeeded in extracting a complete ancient human genome from the pitch seen in the photo. Credit: Theis Jensen

    ‘It is amazing to have gotten a complete ancient human genome from anything other than bone,’’ says Associate Professor Hannes Schroeder from the Globe Institute, University of Copenhagen, who led the research.

    ‘What is more, we also retrieved DNA from oral microbes and several important human pathogens, which makes this a very valuable source of ancient DNA, especially for time periods where we have no human remains,’ Hannes Schroeder adds.

    Based on the ancient human genome, the researchers could tell that the birch pitch was chewed by a female. She was genetically more closely related to hunter-gatherers from the mainland Europe than to those who lived in central Scandinavia at the time. They also found that she probably had dark skin, dark hair, and blue eyes.

    Chewing gum, all-purpose glue or medicine

    • Birch pitch is a black-brown substance that is produced by heating birch bark. It was commonly used in prehistory for hafting stone tools as an all-purpose glue. The earliest known use of birch pitch dates back to the Palaeolithic.
    • Pieces of birch pitch are often found with tooth imprints suggesting that they were chewed. As the pitch solidifies on cooling, it has been suggested that it was chewed to make it malleable again before using it for hafting etc.
    • Other uses for birch pitch have also been suggested. For example, one theory suggests that birch pitch could have been used to relieve toothache or other ailments as it is mildly antiseptic. Other theories suggest, people may have used it as a kind of prehistoric tooth brush, to suppress hunger, or just for fun as a chewing gum.

    Sealed in mud

    The birch pitch was found during archaeological excavations at Syltholm, east of Rødbyhavn in southern Denmark. The excavations are being carried out by the Museum Lolland-Falster in connection with the construction of the Fehmarn tunnel. 

    ‘Syltholm is completely unique. Almost everything is sealed in mud, which means that the preservation of organic remains is absolutely phenomenal,’ says Theis Jensen, Postdoc at the Globe Institute, who worked on the study for his Ph.D. and also participated in the excavations at Syltholm. 

    ‘It is the biggest Stone Age site in Denmark and the archaeological finds suggest that the people who occupied the site were heavily exploiting wild resources well into the Neolithic, which is the period when farming and domesticated animals were first introduced into southern Scandinavia,’ Theis Jensen adds.  

    This is reflected in the DNA results, as the researchers also identified traces of plant and animal DNA in the pitch – specifically hazelnuts and duck – which may have been part of the individual’s diet.

    Bacterial evolution

    In addition, the researchers succeeded in extracting DNA from several oral microbiotas from the pitch, including many commensal species and opportunistic pathogens. 

    ‘The preservation is incredibly good, and we managed to extract many different bacterial species that are characteristic of an oral microbiome. Our ancestors lived in a different environment and had a different lifestyle and diet, and it is therefore interesting to find out how this is reflected in their microbiome,’ says Hannes Schroeder.

    The researchers also found DNA that could be assigned to Epstein-Barr Virus, which is known to cause infectious mononucleosis or glandular fever. According to Hannes Schroeder, ancient “chewing gums” bear great potential in researching the composition of our ancestral microbiome and the evolution of important human pathogens.’

    ‘It can help us understand how pathogens have evolved and spread over time, and what makes them particularly virulent in a given environment. At the same time, it may help predict how a pathogen will behave in the future, and how it might be contained or eradicated,’ says Hannes Schroeder.

    The study was supported by the Villum Foundation and the EU’s research program Horizon 2020 through the Marie Curie Actions.

    Reference: “A 5700 year-old human genome and oral microbiome from chewed birch pitch” by Theis Z. T. Jensen, Jonas Niemann, Katrine Højholt Iversen, Anna K. Fotakis, Shyam Gopalakrishnan, Åshild J. Vågene, Mikkel Winther Pedersen, Mikkel-Holger S. Sinding, Martin R. Ellegaard, Morten E. Allentoft, Liam T. Lanigan, Alberto J. Taurozzi, Sofie Holtsmark Nielsen, Michael W. Dee, Martin N. Mortensen, Mads C. Christensen, Søren A. Sørensen, Matthew J. Collins, M. Thomas P. Gilbert, Martin Sikora, Simon Rasmussen and Hannes Schroeder, 17 December 2019, Nature Communications.
    DOI: 10.1038/s41467-019-13549-9

    DNA Evolution Genetics Popular University of Copenhagen
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    75 Comments

    1. Daniel Alamanda phillips on December 18, 2019 4:46 am

      So we have found our Super-grand Mother.

      Reply
    2. slipknot on December 18, 2019 7:13 am

      wow the amount of things we can learn from the smallest things

      Reply
    3. kaleb wake on December 18, 2019 7:23 am

      this is craaaaazy

      Reply
    4. Ericka & Earl Laporte on December 18, 2019 7:31 am

      I want to thank you folks for your time on your endless work that not only helps me but also other ‘ misplaced Scandinavians’ on where we and others come from. Thank you

      Reply
    5. Carol on December 18, 2019 7:45 am

      this discovery is phenomenal! It could be a doorway to unlimited discoveries of how our bodies REALLY work and the possibilities for cures of all disease are now on the horizon!

      Reply
    6. prognosis on December 18, 2019 9:13 am

      So, if it looks like humanity is going to go extinct, we can basically re-clone our population by scraping the underside of high-school desks…

      Reply
    7. Hungary Hippoo on December 18, 2019 10:13 am

      Amazing! A 5,700-year-old teenager who stared straight into the camera without scowling and showing disrespect for the person who took her gum!

      Reply
    8. Gary W VanOpdorp on December 18, 2019 10:42 am

      L O L A Lola la-la-la-la Lola

      Reply
    9. Michael G Lewis on December 18, 2019 11:15 am

      Would not be surprised if the human population split in the evolutionary stream, so that warlike tendencies disappear (especially after the atomic bomb and other nuclear weapons) and more peaceful humans endured in evolutionary time – like, millions of years. God told us not to mess with the center of things. Bad dinos like T. Rex were also sent to Hell.

      Reply
      • bill on December 18, 2019 12:55 pm

        Unfortunately, humans have seemingly become more war like since the advent of the bomb. Until the T-Rex went to hell, you had a great post.

        Reply
    10. Kamal on December 18, 2019 11:23 am

      Chewing a gum 5, 000 years ago!!!! Ok !? Is it a gum or other thing from their body ?

      Reply
      • Nikki on December 19, 2019 11:10 am

        Kamal, the term chewing gum was used in parentheses throughout the article, because that is what to the modern eyes it most replicates. The actual substance is ‘birch pitch,’ which was chewed on regularly by members of this community. The article acknowledges scientists are not certain why stone age peoples chewed birch pitch.

        Reply
    11. Tommy on December 18, 2019 11:54 am

      This is why I collect my used gum and throw it in the fireplace.

      Reply
    12. Joe blow on December 18, 2019 11:54 am

      This is such BS!! If anyone believes this you are an idiot!

      Reply
      • Bill on December 18, 2019 12:53 pm

        Such a limited mind, disallows any place knowledge can be found. Expand your knowledge horizon and many possibilities become available.

        Reply
        • Mark Seibold on December 18, 2019 1:36 pm

          This is why we have the modern world of investigative science today, rather than others that just want to recite a religious prayer.
          Yet you see those same people still here in the comments today, quoting fairy tales out of a book from a thousand years ago.
          Research this and see Carl Sagan’s last interview with Charlie Rose, why many people still today in our world just want to do what makes them feel good instead of exercising real scientific methods of investigation.

          Reply
      • Nikki on December 19, 2019 11:14 am

        Can you explain why you believe it is B.S.? And please don’t say: ‘it just is? ‘It can’t be true’ or ‘anyone who believes you can extract DNA from Birch Pitch is dumb’ because that is not a legitimate argument. Thank you.

        Reply
    13. John McCall on December 18, 2019 12:39 pm

      The scientists, while not dumb, could not understand why she walked like a woman and talked like a man.

      Reply
    14. Eric R Wiksten on December 18, 2019 12:44 pm

      It turns out Fruit Stripe lost all it’s flavor in 30 seconds back then, too.

      Reply
      • Orson on December 18, 2019 10:21 pm

        You win the comments.

        Reply
    15. Mark Seibold on December 18, 2019 1:29 pm

      This is why we have the modern world of investigative science today, rather than others that just want to recite a religious prayer.

      Reply
    16. Mark Y. on December 18, 2019 2:50 pm

      Fake News! This is ridiculous. This is typical click bait. Scientist cannot be this stupid surely.

      Reply
      • Anonymous on December 19, 2019 7:10 am

        You can deny it, but the truth is that it’s 100% factual. Just because you don’t believe in genetics and science doesn’t mean it’s fake. Open your mind to more things and over time you will see the bigger picture.

        Reply
    17. Henry on December 18, 2019 3:05 pm

      Yeah , such a BS article .. running with their diversity agenda on full speed .. so the color of skin is brown too ? LoL

      Reply
    18. Eyes open on December 18, 2019 3:25 pm

      Wonderful! Ignorance is at least remedied, stupidity? We all know that answer! Is it Bulls#!t because you IQ is ,let me guess 79-80? Do you honestly believe you and your child(man created Eve/incest) and yourselfand along with a voice in the sky for questionable guidance, fathered humanity?! Of course you do, human cattle is relentlessly predictable

      Reply
    19. Jermel on December 18, 2019 3:26 pm

      It is appearing that the ancient people of Europe were essentially black. However, their presence has almost been erased by the presence of inbreeding. As well as Neanderthal human hybridization.

      Reply
    20. JMF on December 18, 2019 3:28 pm

      She does not look Scandinavian to me. Wonder if the scientists were trying to be politically correct to please the new migrants.

      Reply
      • OhGee on December 18, 2019 10:22 pm

        See Indigenous People of Northern Europe; Laplanders, or differently named, The Sami. Many have a dark complexion, some do not.

        Reply
        • JMF on December 19, 2019 9:33 am

          Perhaps dark hair but not dark complexion. Eskimos have dark hair and dark eyes but fair skin.

          Reply
          • Jenny on December 19, 2019 5:24 pm

            Eskimos came from the Mongoloid race…not comparable. The first European races would have dark skin because early human species came from warm climates and spread to colder climates.

            Reply
            • JMF on December 20, 2019 9:47 am

              That might be true, but there’s no reason to allow the current second massive migration from the middle East and Africa to Europe or the warmer climates as you say

            • SharElaine on August 23, 2021 9:13 am

              We all came from Africa.
              Australopithicus.
              Go visit Sterkfontein caves in S.Africa and you cannot fail to be moved inexplicably.I did.

    21. Abletounderstand on December 18, 2019 3:52 pm

      So surprised the inane remarks came from a Joe, John, Mark & Henry. Actually, I cannot figure how they found and understood the article, perhaps a detention assignment.

      Reply
    22. featherknife on December 18, 2019 4:06 pm

      The people who find this information unbelievable crack me up. Humanity was once what we describe as black people today. Eyes were dark. Science already knows through DNA analysis, when blue eyes began appearing due to a mutation. The melanin in our skin decreased over time because humanity was migrating from the part of the planet that is bombarded by UV rays more than anywhere else, to, in this case, the far northern ranges where UV rays are at their lowest point. Data, which we find and utilize with ever increasing accuracy and quantity, reveal a diaspora, and evolutionary arc which is validated over and over again, and is clearly understandable to the average person with an open mind. Unless, I suppose, you want to believe in magic, or alien intervention. If that is the case, your arguments belong in comic books, not here.

      Reply
      • JMF on December 18, 2019 4:45 pm

        So what you’re saying is, all the new dark-skinned migrants will look like blond-haired, blue-eyed Scandinavians in 5,700 years. So nothing to worry about because in 5,700 years the crime wave in Scandinavian cities will stop. The Swedes in Malmo will be happy to hear that.

        Reply
    23. John Cena on December 18, 2019 4:13 pm

      So does that mean we can discredit the man John Curtis who claims to make the first piece of gum back in 1840s?? Because…

      Reply
    24. Amalgama on December 18, 2019 6:36 pm

      I wonder if her DNA is similar to the man from La Braña, León, Spain who was determined to have had darker skin and hair and blue eyes and had the same DNA as other Homo Sapiens in northern Europe

      Reply
    25. Jeremy on December 18, 2019 10:44 pm

      First of all the comment section is a bit disappointing. It’s not necessary for the secular atheist religion to attack the monotheistic faiths that adopted polytheistic practices for their own in the 4th century CE. Faith is a major part of both belief systems. Unless anyone was there when everything came about and can verify with the scientific method what happens to our concienceness when we die then we are fundamentally operating on faith that what we believe is correct. Secondly the article is making some pretty big assumptions about the genetic material. Sure, some things can be deciphered but the time period is guess work. This young woman could simply be the off spring of a captive brought back and a Nordic father. After all the genetic information is using mitochondrial DNA. With no actual body all the rest is supposition. Nonetheless what can be uncovered is fascinating and is adding another piece to a rapidly changing understanding of our ancient and prehistoric past.

      Reply
    26. Robert Mize on December 19, 2019 12:19 am

      This is very cool but won’t lead to the utopia dreamed of by leftists and the science dilettante.

      Reply
    27. Travis on December 19, 2019 12:58 am

      Umm…im pretty sure that’s just an ancient petrified turd…. it looks like a little piece of s#!t I mean really what will they think of next how do they even know what this is if its 5000 years old no f@#king way a piece of gum would last that long no way that’s just f@#king crazy man it’s impossible

      Reply
    28. Deavman on December 19, 2019 1:56 am

      So they found a piece of gum somewhere in a scandinavian dig, dated it at about 5700years old, and they figured she looked asian. Yeah right, i believe you.

      Reply
    29. Floyd on December 19, 2019 3:38 am

      How do they know she is 5,700 years old, and isn’t transgender?

      Reply
    30. Bil Vic on December 19, 2019 4:01 am

      The world today needs great people like you and your group more so in the world of science and discovery, i believe through the tireless endeavors and urge to discover even what seems problematic to human race like HIV/AIDS cure Wi’ll become history we thank u so much

      Reply
    31. Bil Vic on December 19, 2019 4:10 am

      This discovery suspects her having had dark skin and black hair, it’s 5700 years ago before Christ, should we assume that its true the early man right from Adam and Eva through the ages where dark skinned and had black hair just like Africans as its always said? Should we say then white man colour is just due to evolution over time?

      Reply
    32. Factoid on December 19, 2019 4:27 am

      First, I guess no one noticed it wasn’t actual gum, it was birch pitch (derived from the dry distillation of the bark of the birch tree, about 125000 to 75000 year old practice). Additionally, this information is also available through the Smithsonian and National Geographic, address they not viable sources of information?? The final point is directed at those that question because of how old the films is said to be… does no one remember Lucy, or the Iceman?? This is 2019, science has come a long way.

      Reply
    33. Stephanie on December 19, 2019 5:04 am

      I know someone that look exactly like her twins

      Reply
    34. Edwin Hidalgo on December 19, 2019 6:00 am

      Most of these comments remind me of the German press around 1934 to 1939, trying to discredit Einstein’s two theories of Relativity. Pure ignorance. People nowadays never read enough

      Reply
      • Moneva on December 19, 2019 7:35 am

        Most people of this day and age are unfortunately dumbed down to a point where they are illiterate. Being illiterate does not mean that they cannot decipher words. But it means, they are incapable of grasping the meaningful content of any written message. Must be because this skill is not necessary to read messages on fake book. And that’s all they ever read.

        Reply
    35. Rigr Ault on December 19, 2019 7:23 am

      More, “We wuz kangz” BS!

      Reply
    36. Paul on December 19, 2019 7:43 am

      Why is it so hard to accept that modern humans evolved from Africans? Accepting that fact doesn’t make Europeans any less European.

      Reply
      • Gabe on December 19, 2019 10:39 am

        You really don’t understand how pictures like this are designed to propagandize Europeans into thinking they don’t have a right to borders? The out of Africa theory has also been debunked. Newer evidence shows human groups which are native to the areas outside of Africa.

        Reply
    37. Kay on December 19, 2019 8:13 am

      Migration from areas where more melanin is needed accounts ligtening of features over time. It’s not evolutionary as evolution is farce. It is however what could be called an adaptation. Honestly, it could even be as simple as the climate being different then. What’s in fact not true, and totally racist, is to say that modern humans are an evolutionary step from Africans. LORD!

      Reply
    38. John Jacob Schmitt on December 19, 2019 8:48 am

      I always enjoy the biased imaginations of the artists who think they can render a picture of someone from thousands of years ago when they most likely know nothing at all about genomes. Genomes by themselves do not give enough information on appearance.

      Reply
      • Gnomio on December 19, 2019 8:37 pm

        Right! She didn’t even have a long white beard or a pointy red hat.

        Reply
    39. Skol Jack on December 19, 2019 9:15 am

      Science, intelligence and religion can coexist. For many, myself included, religion is a “way” to live our lives now to prepare for the next. Whereas science and intellect are a gift. A gift given to continue or “evolve” the story of our species. The giver of these gifts maybe up for speculation, but the fact is, we were given these gifts and I applaud all who use them for the betterment of humanity. Does the female’s skin complexion really matter anyway? Does it change any of our outlook on life? I would place my wager on no. What if God used the big bang as his/her means of creation? And last but not least, as Forest once poetically prophesied, “s#!t happens” and then we die or until the next click bait catches your eye.

      Reply
      • Gabe on December 19, 2019 10:35 am

        The skin complexion does matter. This is science. A study of the human groups native to different areas of the world. That may conflict with your understanding of Europe as gleaned from mass media in which they act like Somalians are as native to Sweden as Sweedes.

        Reply
    40. Debbie on December 19, 2019 9:19 am

      We live close to Grandfather Mountain in North Carolina and years ago archaeologists came to study it and they found deep grooves in the rocks on the side of the mountain. They said it was from the glaciers thousands of years ago. My husband grandfather laughed at this and said he knew exactly how they were made. He said several years of logging on the mountain with very heavy chains made those grooves. He would know he helped with the logging.

      Reply
    41. PB on December 19, 2019 9:29 am

      What is her mtdna haplogroup?

      Reply
    42. The truth on December 19, 2019 9:55 am

      Sounds like they where black??

      Reply
    43. Robert macintyre on December 19, 2019 10:00 am

      It’s like when they show us a picture of our galaxy ?

      Reply
    44. Gabe on December 19, 2019 10:32 am

      Uhh, no one with a brain believes native europeans had dark skin. The out of Africa theory has been debunked.

      Reply
      • Nikki on December 19, 2019 11:22 am

        No quite, the out-of-Africa theory is not debunked, but new links have been found through the discovery of more ancient fossils. They are unsure about the links, so more information is needed. Here is an article from Harvard News in 2018:
        http://sitn.hms.harvard.edu/flash/2018/oldest-human-fossil-found-outside-africa-sheds-light-behavior-early-homo-sapiens/

        Reply
    45. Nikki on December 19, 2019 11:16 am

      Hahaha witty!

      Reply
    46. Yours Truly on December 19, 2019 11:29 am

      Can’t understand how that red named Mark Seibold is “single”

      Poor guy. Stay in your bubble.

      Reply
    47. Geri A. Mellgren-Kerwin on December 19, 2019 11:34 am

      As the article says at the beginning, this new source of genetic evidence is great in those cases where the usual source, human bones, is seldom found due to local conditions. Some of the gaps in our history may be filled.

      Reply
    48. RW on December 19, 2019 12:49 pm

      Interesting how science can determine the gender of a humanoid off of a 5,700 year old piece of gum, but today we got people who can’t figure out if they are male or female even though their own DNA is crystal clear in regards to their gender.

      Reply
    49. Sharpline on December 19, 2019 1:36 pm

      What a beautiful mulatto,like I expected. Wow do I feel smart. Seems like today’s rap music has some affect on what people looked like thousands of years ago lol.

      Reply
    50. Larry on December 19, 2019 4:00 pm

      They only found it coz she left it on the bedpost overnite.

      Reply
    51. Bob Waters on December 19, 2019 4:39 pm

      Female you say? I wonder what her pronouns were.

      Reply
      • Monty on December 19, 2019 8:32 pm

        Ha! Her pronouns. Wink wink nudge nudge say no more say no more.

        Reply
    52. rivenburg on December 19, 2019 4:55 pm

      Those who trip on the conclusions should read a bit, genomics has advanced to where a chinese company can show you what your children will look like. not a joke. also, the dark skin wasnt black, but mohogany red tinted like the blue eyed Cherokee. there were at least two ice age populations in europe descended from at least two different human/neanderthal hybridization events, in all ive counted at least 5 different white populations from distinct hybridization events. Of the two in western europe, one had white skin and one blond hair, both had blue eyes. most of us whites are a hybrid of those two plus a slav hybrid event creating the eurasians. the fins might be another. all slightly different and different from the other white groups like the aiainu of japan, Jomon culture and Kenniwick man.

      Reply
    53. Dinero on December 19, 2019 8:29 pm

      We all know it wasn’t gum. They can not legally talk about what it really is. Back in that time they worked items into a workable state by chewing. If you look at it you can easily tell what it is, it’s a tide pod. They can’t say it because some dumb*ss will start chewing it to keep the heritage alive.

      Reply
    54. SamiRose on December 19, 2019 8:55 pm

      There is only ONE source where we will find ALL truthful answers..

      Reply
    55. Transtime on December 19, 2019 9:28 pm

      Maybe she bought the chewing gum at an extinct supermarket like K-Mart…

      Reply
    56. Justwantthetruth on December 21, 2019 3:06 pm

      “Probably had dark skin “. Unless there is DNA that can guarantee skin pigment why was “probably dark skin” rather than probably white? The entire location is predominantly white. I find it hard to believe a short period of 5700 years changed the indigenous people from a tan pigment to white. Unless pigmentations can be a factual determination just say it is indeterminate. Europeans have every right to contest this. When it was found that 5000 year old mummies in North Africa had Caucasian DNA there sure was an uproar about that. That news got quieted pretty quick. But only whites get criticized for questioning ethnicity.

      Reply
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